Chem 781 In class presentations:

Each student chooses one of the listed research articles and explains it to the class on the date indicated as a 20 min presentation.

The presentation is expected to contain both the specific application mentioned in the article and a more general description of the NMR method applied which may require the use of additional articles mentioned in the paper.

Presentations must be discussed with the instructor at least a week prior to the scheduled presentation date. Dates listed below are tentative until a final assignment has been made.

1. ¹H-NMR without deuterated solvents (10/6): Eric Bloch Thomas R. Hoye, Brian M. Eklov, and Mikhail Voloshin "No-D NMR Spectroscopy as a Convenient Method for Titering Organolithium (RLi), RMgX, and LDA Solutions" Org. Lett., 2004, 6(15), 2567-2570 and relevant references therein
2. Analyzing multiplet patterns: (10/6): Tang Xiong
Thomas R. Hoye and Hongyu Zhao; "A Method for Easily Determining Coupling Constant Values: An Addendum to 'A Practical Guide to First-Order Multiplet Analysis in ¹H NMR Spectroscopy' "; J. Org. Chem. 2002, 67, 4014-4016 and references therein
3. Sensitivity enhancement of low- nuclei:Adam Nothnagel(10/20) B. Wrackmeyer, O. L. Tok, M.Herberhold; "⁵⁷Fe NMR of Ferrocenes by ¹H-⁵⁷Fe INEPT Techniques" Organometallics 2001, 20 (26), 5774 -5776
4. Application of ¹⁵ N correlation spectroscopy: Cory Hawkins(10/27)Simone Zaramella, Petri Heinonen, Esther Yeheskiely, and Roger Strömberg; "Facile Determination of the Protecting Group Location of N^im-Protected Histidine Derivatives by ¹H-¹⁵N Heteronuclear Correlation NMR" J. Org. Chem. 2003, 68, 7521-7523 OR Damblon, C.; Prosperi, C.; Lian, L.-Y.; Barsukov, I.; Soto, R. P.; Galleni, M.; Frere, J.-M.; Roberts, G. C. K.; "¹H-¹⁵N HMQC for the Identification of Metal-Bound Histidines in ¹¹³Cd-Substituted Bacillus cereus Zinc -Lactamase "; J. Am. Chem. Soc. 1999, 121(49), 11575-11576.
5. Automated structure elucidation: UddinNazim(11/24) Jochen Junker, Walter Maier, Thomas Lindel, and Matthias Köck; "Computer-Assisted Constitutional Assignment of Large Molecules: COCON Analysis of Ascomycin " Org. Lett., 1(5), 1999, 737-740 also briefly mention Köck M, Junker J, Lindel T; "Impact of the H-1,N-15-HMBC experiment on the constitutional analysis of alkaloids"; Org. Lett. 1999, 1 (13), 2041-2044
6. Measuring Binding Constants by NMR using chemical shift change: Robert Hoppe (10/20) Ian Horman, Bernhard Dreux ; "ESTIMATION OF ASSOCIATION CONSTANTS OF BIMOLECULAR ORGANIC-COMPLEXES"; Anal. Chem. 1983, 55, 1219-1221 and relevant part of Lee Fielding; "Determination of Association Constants (K_a) from Solution NMR Data"; Tetrahedron 2000, 56, 6151-6170.
7. Dipolar Coupling constants in Solution: Alan Pawlak (10/27) Christoph Naumann, William Bubb, Bogdan Chapman, Phillip Kuchel, "Tunable-Alignment Chiral System Based on Gelatin for NMR Spectroscopy"; J. Am. Chem. Soc. 2007, 129(17), 5340-5341.
8. Para Hydrogen Induced Polarization: Richard Sniatynsky (11/24) Thomas Eisenschmidt, Rein Kirss, Paul Deutsch, Sven Hommeltoft, Richard Eisenberg, "Para Hydrogen Induced Polarization in Hydrogenation Reactions"; J. Am. Chem. Soc. 1987, 109(26), 8089-8091 and ref. 9c therein.
9. Use of Deuterium Isotope shifts: Nathalia Stein (10/15) J.W. Akitt, Julie M. Elders, Xavier L.R. Fontaine; "Hydrogen-Deuterium Isotope Effects in the Proton N.M.R. Spectra of Hydrated Al(III) Species", J. Chem. Soc., Chem. Commun. 1986, 1047-1049. AND John C. Christofides and David B. Davies; "Secondary Isotope "Multiplet NMR Spectroscopy of Partially Labeled Entities. Carbon-13 SIMPLE NMR of Carbohydrates" J. Am. Chem. SOC. 1983, 105, 5099-5105